PGE2-JNK SIGNALING AXIS NON-CANONICALLY PROMOTES GLI ACTIVATION BY PROTECTING GLI2 FROM UBIQUITIN-PROTEASOMAL DEGRADATION

PGE2-JNK signaling axis non-canonically promotes Gli activation by protecting Gli2 from ubiquitin-proteasomal degradation

Abstract Both bench and bedside investigations have challenged the supportive role of Hedgehog (Hh) activity in the progression of colorectal cancers, thus raising a critical need to further deeply determine the contribution of Hh to the growth of colorectal cancer.Combining multiple complementary means, including in vitro and in vivo inflammatory

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Structural enhancement of ZnO on SiO2 for photonic applications

Multi-layer thin films are often the basis of photonic devices.Zinc oxide (ZnO) with its excellent optoelectronic properties can serve as a high quality emitter in structures like microdisks or photonic crystals.Here, we present a detailed study on the enhancement of the Bandai Spirits structural properties of low-temperature MBE grown ZnO on silic

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Methotrexate and mucositis: A merry-go-round for oncologists

High-dose methotrexate is the backbone of various regimens for treating lymphoid malignancies.Mucositis is a well-known, dose-related side GOLDEN FLAX SEED GROUND effect of methotrexate.Prophylactic measures such as folinic acid rescue are useful but do not prevent mucositis in all the cases.Once severe mucositis (WHO Grade IV) sets One Daily Multi

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Am I Way Wrong on this One? On the Multiple Semantic Sources and Paths of Development of the Amplifier Way in American English

This article explores the diachronic semantic development of the intensifier way in American English.It has been claimed in the literature that the intensifying function of way derives from the use of spatial adverbial (a)way, but I propose that this may not be the only semantic source involved.This assumption is based on an examination of corpus d

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